For patients with schizophrenia, clozapine (CLZ) in combination with clonazepam (CLNAZ) is one of the viable therapeutic options
Clonazepam Clothiapine Clozapine Cobicistat Codeine Conivaptan Crizotinib Cyclobenzaprine Cyclopentolate Cyclosporine Cyproheptadine Dabrafenib Daridorexant
It behaves as a GABA-A receptor agonist
1177/2050313X19833254 Abstract This is a case report of a patient who was treated with clozapine and clonazepam after he developed neuroleptic-induced tardive dyskinesia
What is
Clozapine remains an effective drug against treatment-resistant schizophrenia, defined as failing treatment with at least two different antipsychotic
This is the name used by doctors to describe a disordered state of mind
The structural formula is
78% of reviewers reported a positive effect, while 12% reported a negative effect
Descriptions
Clozapine is a second generation antipsychotic
pains in the stomach, side, or abdomen, possibly radiating to the back
swelling of the body or feet and ankles
Using Clozaril with other drugs that make you drowsy or slow your breathing can cause dangerous side effects or death
However, benzodiazepines are also commonly used to treat difficulty sleeping and alcohol withdrawal
Clozapine was first discovered in 1959 by scientists at Wander Laboratories, who were screening tricyclic compounds for anti-depressant activity and were surprised to discover drugs with a chemical structure comparable to the tricyclic anti-depressants but with antipsychotic properties (Naheed & Green, 2001)
Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical"
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness Clozapine has been found to be an effective treatment in persons with schizophrenia resistant to treatment with other antipsychotic drugs
Clozapine is also FDA approved for the reduction in suicidal behavior in schizophrenia or schizoaffective disorder and effective for treatment-resistant mood disorders
Prescription only
This side effect occurs in less than 1 out of every 100 people who take this medicine
Take exactly as directed by your doctor