The nonreducing polyketide synthase gsfA initiates the synthesis of griseofulvin by combining one acetyl-CoA and six malonyl-CoA units to form the heptaketide backbone of benzophenone 5a
A stereospecific synthesis of griseofulvin Samuel Danishefsky and Frederick J
semisynthesis from griseofulvin and by de novo synthesis
Chemistry
Objectives: Describe the therapeutic mechanism of action of griseofulvin
To elucidate essential genes involved in griseofulvin biosynthesis, we performed third-generation sequencing to obtain the genome of P