It may increase serotonin activity in your brain
Do not use trazodone with buspirone (Buspar®), fentanyl (Abstral®
While trazodone is not a true member of the selective serotonin reuptake inhibitors (SSRIs) class of antidepressants, it does still share many properties of the
Trazodone is a type of antidepressant called a serotonin receptor antagonist and reuptake inhibitor (SARI)
Serotonin is one of the chemical messengers (neurotransmitters) that carry signals
It’s known that it inhibits two types of serotonin receptors in the brain, which can increase levels of serotonin
Does trazodone alone cause serotonin syndrome? Yes, trazodone can cause serotonin syndrome when used in higher or more frequent doses
Initial dose: 150 mg orally per day in divided doses; this may be increased by 50 mg orally per day every 3 to 4 days
Withdrawal effects may occur within 5 days of stopping treatment with antidepressant drugs; they are usually mild and self-limiting, but in some cases may be severe
Continuing dryness of the mouth may increase the chance of dental disease, including tooth Serious side effects of Trazodone
While no association between trazodone and bleeding events, in Trazodone hydrochloride tablets may cause somnolence or sedation and may impair the mental and/or physical ability required for the performance of potentially hazardous tasks
Constipation
If you notice any other effects, check with your healthcare professional
Take trazodone exactly as your doctor has told you to
Call your doctor at once if you have: serious infections, or prevention of nausea and vomiting
If your dose is 300mg a day or less, your doctor will probably tell you to take it as a single dose at bedtime
You could have more side effects
The major neurotransmitters are acetylcholine, norepinephrine, dopamine, and serotonin
Trazodone is an antidepressant that’s sometimes prescribed off-label for sleep
Trazodone is considered safe to take for short-term insomnia symptoms
Trazodone is taken orally, typically starting at a low Serotonin Syndrome: Increased risk when co -administered with other serotonergic agents (e
• drugs that also increase the QT interval and in patients with risk factors for prolonged QT interval (5
Common side effects
Maximum dose: 400 mg per day in divided doses ( 2 )