Abstract
Reversible agranulocytosis associated with oral terbinafine for onychomycosis
Authors
We report a case of terbinafine-induced agranulocytosis in a pediatric patient
Terbinafine: agranulocytosis Prescrire Int
Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate
White blood cells are part of your immune system
Oral granules are used to treat a fungal infection of scalp hair follicles in children who are at least 4 years old
Blood and lymphatic system disorders: Pancytopenia, agranulocytosis, severe neutropenia Significant: Depression, taste or smell disturbance, severe neutropenia, agranulocytosis, pancytopenia, thrombocytopenia, precipitation and exacerbation of cutaneous and systemic lupus erythematosus, exacerbation of psoriasis
Prescribe terbinafine with caution to people with: Autoimmune disease — risk of lupus erythematosus-like effect
Since its launch, terbinafine has garnered the top slot among topical antifungals and the oral formulation is estimated to have captured nearly 80% of the greater than US$1
The mean age of the participants was 64 years (range 35-79 years)
Bodyweight 20–39 kg, prescribe 125 mg once daily for 4 weeks
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Peak plasma concentrations of 1 μg/mL appear within 2 h after a single 250 mg dose; the AUC (area under the curve) is approximately 4
Typing is only just possible! Oral terbinafine has been available in the United States since 1996
, Depression, taste or smell disturbance, severe neutropenia, agranulocytosis, pancytopenia, thrombocytopenia, precipitation and exacerbation of cutaneous and systemic lupus erythematosus, exacerbation of psoriasis
terbinafine, however, is seemingly related to the toxic effects of squalene accumulation rather than the depletion of membrane ergosterol