The rate of serious rash is greater in pediatric patients than in adults
73% of reviewers reported a positive effect, while 16% reported a negative
However, some doctors prefer to split the dose to decrease the risk of side effects such as drowsiness
At the same time, large interindividual variability is detected in LTG pharmacokinetics and pharmacodynamics
Lamotrigine (LTG) is a broad-spectrum anti-epileptic drug (AED) widely prescribed for the treatment of epilepsy and psychiatric disorders
6 mg/kg/day orally in 2 divided doses (week 1 and 2), then 1
Of the total drug interactions, 9 are major, 263 are moderate, and 12 are minor
Vaiva Petrenaite *, Inger Öhman, Frederik Peter Thal Jantzen, Lena Ekström UGT2B15 and UGT 2B17) and the transporter protein ABCB1 on Lamotrigine (LTG) metabolism
In contrast, 10 μM ritonavir treatment for 72 h was associated with decreased lamotrigine glucuronidation
Lamictal passes into breast milk and can cause side effects in breastfed children
UGT1A3, A4, A6, A8, A9, A10, UGT2B7, UGT2B15, and β-oxidation in the mitochondria (using carnitine as carrier) Possible higher levels of valproic acid by inhibition of UGTs or higher levels of cannabinoids due to valproic acid UGT inhibition
, 2004)