In these trials a total of 13,797 patients with erosive GERD were included
Pantoprazole and rabeprazole (100%) were more effective vs omeprazole (89
Both omeprazole and its S enantiomer (esomeprazole) have been available and used to treat symptoms of gastroesophageal reflux disease (GERD) and conditions
A significant difference between esomeprazole 20 mg and omeprazole 40 mg (RR=0
The difference in endoscopic healing rates was 10% after 4 weeks and 4
The tolerability
Otherwise, no significant differences
51% of reviewers reported a positive effect, while 36% reported a negative effect
Clinical trials have shown that pantoprazole and esomeprazole are similarly effective
Although the CYP2C19 pathway is dominant overall, individual agents have variations which have led to concerns over efficacy and drug-drug interaction
Omeprazole can be obtained over-the-counter (OTC) or via prescription (Rx), while pantoprazole is an Rx-only medication
The results suggested that ilaprazole, esomeprazole, and vonoprazan have more advantages compared with other PPIs in mucosal erosion healing, while the safety of vonoprazan was similar to PPIs
Nexium (esomeprazole magnesium) and Prilosec (omeprazole magnesium) are two medications in a drug class called proton pump inhibitors, or PPIs
No comparative studies of esomeprazole vs omeprazole or rabeprazole in maintenance therapy of healed erosive GERD could be found
Among other
Ranitidine is a medication available over-the-counter or by prescription for the treatment of gastroesophageal reflux
Omeprazole and lansoprazole are the first and second generations of PPIs, respectively, to specifically inhibit the proton pump h +, k +, and ATP enzyme activity of gastric parietal cells, resulting in the strong and continuous
It is prescribed for the same conditions, including GERD, peptic ulcers, and Zollinger-Ellison syndrome
The main difference lies in their slightly different chemical compositions
7% vs 84
A greater acid inhibitory effect of esomeprazole vs R-omeprazole and omeprazole racemate was obtained on pentagastrin-stimulated peak acid output in healthy subjects 2'
The paper assesses the safety and tolerability of esomeprazole in pediatric and adolescent patients