This CME activity reviews the etiology, epidemiology, mechanism of action, pathophysiology, toxicokinetic, and histopathology of valproate
VPA is derived from valeric acid (naturally produced by valerian, Valeriana officinalis) and was first synthesized in 1882
Valproic Acid is an 8 carbon branch carboxylic acid (formerly named 2-propylvaleric Acid)
Valproic acid (2-propylvaleric acid, 2-propylpentanoic acid or n-dipropylacetic acid) (see Figure 1(a)), derived from valeric acid (Figure 1(b)) (naturally produced by valerian, Valeriana officinalis) (see Figure 1(c)), was first synthesized in 1882 by Burton []
Researchers found that i sovaleric acid, a chemical contained in this herb, may prevent convulsions, similar to the effects of the anticonvulsant medication valproic acid
The dosage should be increased by 5 to 10 mg/kg/week to achieve optimal clinical response
Continue levocarnitine therapy for at least 72 hours
Valproic acid is not suitable for girls or women who could become pregnant
Valproic acid has not been systematically studied as initial therapy
The risk of developing liver damage is greater in children who are younger than 2 years of age and are also taking more than one medication to prevent seizures, have certain inherited diseases that may prevent the body from
Valproic acid is highly protein bound to albumin with typical values of 90–95%
1)Suspected POLG-related disorder in children under two years of age (4, 5
Serum levels of 50-100 mcg/mL are considered therapeutic, with minimal risk of toxicity when
CYP2C9, primarily responsible for hydroxylation and 4-ene desaturation of valproic acid, is a polymorphic enzyme with the highest frequency of CYP2C9*2 and CYP2C9*3 alleles in Caucasian white Warning