[18] Serious side effects of Lipitor that have been reported include: irregular results of liver function tests, which could be a sign of liver damage
The patient's medication list should be analyzed using a drug interaction database (Lexicomp drug interactions) whenever therapy is adjusted
Examples include fenofibrate (Tricor), which is available in several different formulations, and gemfibrozil (Lopid)
Lipitor (atorvastatin) is a prescription drug used to treat high cholesterol and to lower certain risks
Gemfibrozil is a lipid-modifying agent that belongs to the fibric acid derivative class
According to the FDA, concomitant (at the same time) use of atorvastatin and gemfibrozil (Lopid) Drug Interactions for Lipitor Drug Interactions That May Increase The Risk Of Myopathy And Rhabdomyolysis With LIPITOR
Anti-Viral Medications: Lipitor is used to treat high cholesterol
Get emergency medical help if you have signs of an allergic reaction to gemfibrozil: hives; difficulty breathing; swelling of your face, lips, tongue, or throat
Pitavastatin (Livalo) Pravastatin (Pravachol) Rosuvastatin (Crestor) Simvastatin (Zocor) Decrease LDL and triglycerides; slightly increase HDL
Gemfibrozil comes only in the form of a tablet you take by mouth
Images Lopid may interact with blood thinners, insulin or oral diabetes medication, or other cholesterol-lowering drugs
Both clofibrate and gemfibrozil may increase cholesterol excretion into the bile, leading to cholelithiasis
52% of reviewers reported a positive effect, while 33% reported a negative Gemfibrozil is used along with a proper diet to help lower fats (triglycerides) and raise good cholesterol (HDL) in the blood
The biggest risk with this interaction is rhabdomyolysis, so assessment of CPK might be an appropriate way to help monitor for the potential interaction between gemfibrozil and statins
The effect of the Article date: January 2008
It has many interactions with other medications, including cholesterol-lowering medications called statins
At the same time, this medication can help raise "good" cholesterol (HDL)
Avoid or Use Alternate Drug
drug-drug interaction (DDI) is a pharmacokinetic or pharmacological influence derivatives gemfibrozil hydroxymethylglutaryl-CoA reductase inhibitors immunosuppressive agents AHA SCIentIFIC StAteMent
0000000000000456 November 22, Gemfibrozil is available in multiple generic forms and under the brand name of Lopid as tablets of 600 mg
Of the total drug interactions, 93 are major, 283 are moderate, and 22 are minor
Always consult your healthcare provider before starting or stopping any medication
Gemfibrozil is used together with a proper diet to treat high cholesterol and triglyceride (fat) levels in the blood
Patients should be placed on a standard lipid-lowering diet before initiation of gemfibrozil therapy and should remain on this diet during treatment with the drug
1
Of the total drug interactions, 21 are major, 115 are moderate, and 1 is minor
Although most myopathy cases occur as a result of drug-drug interactions, statins in monotherapy have also caused myopathy
The phase IV clinical study analyzes what interactions people who take Lipitor and Gemfibrozil have
Check interactions with multiple drugs, vaccines, supplements, alcohol, food and diseases
Statins are medications that have a lot of drug interactions due to how they are broken down in the body
rhabdomyolysis
The risk: Blood levels of lovastatin (Mevacor) and simvastatin (Zocor) can double or triple when combined with gemfibrozil
Major: Highly clinically significant
Comparatively, gemfibrozil is associated with a more significant Fenofibrate has an average rating of 5
It also provides guidance on how to prevent and manage this potentially life-threatening complication
Side effects of Lipitor that are different from Lopid include constipation, fatigue, gas, and heartburn
Tell your doctor right away if you notice any of these serious side effects: nausea / vomiting that doesn't stop, severe stomach/abdominal pain, yellowing eyes / skin
Gemfibrozil (Lopid) is a drug prescribed for certain types of high cholesterol or heart disease
Statins are among the most prescribed medications in the U
Zocor
Gemfibrozil, one of the fibrates, but not fenofibrate, interferes with statin glucuronidation, which may increase the risk of myopathydue to elevations
According to the FDA, drugs that may interact with Lipitor (atorvastatin calcium) include the following: Strong inhibitors of CYP
mild muscle pain
FAQ
Grapefruit and grapefruit juice can interact with many medications, including colchicine
Common side effects of gemfibrozil (Lopid) include indigestion, stomach
If you also take certain other drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take gemfibrozil at least 1 hour before or at least 4-6 hours after There have been several attempts to alert clinicians of the importance of the statin-gemfibrozil drug-drug interactions
Always consult your healthcare provider before starting or stopping any medication
The patient's medication list should be analyzed using a drug interaction database (Lexicomp drug interactions) whenever therapy is adjusted
The risk: Blood levels of lovastatin (Mevacor) and simvastatin (Zocor) can double or triple when combined with gemfibrozil
A total of 105 drugs are known to interact with Lopid : 30 major drug interactions (79 brand and generic names) 74 moderate drug interactions (237 brand and generic names) 1 minor drug interactions (2 brand and generic names) No known drug interactions
Of the total drug interactions, 21 are major, 115 are moderate, and 1 is minor
This isn’t an exhaustive list, but here are some common Paxlovid interactions to be aware of
Avoid or Use Alternate Drug
FDA drug safety communication: Interactions between certain HIV or hepatitis C drugs and cholesterol-lowering statin drugs can increase the risk of muscle injury
Fact sheet for healthcare providers: Emergency use authorization for Paxlovid™
Concomitant use of cyclosporine or gemfibrozil with LIPITOR is not recommended
Drug information provided by: Merative, Micromedex® US Brand Name
The usual dosage is one tablet taken by mouth twice a day before meals
Although not all of these side effects may occur, if they do occur they may need medical attention
Lipitor is used to treat high cholesterol
Of the total drug interactions, 93 are major, 283 are moderate, and 22 are minor
Check interactions with multiple drugs, vaccines, supplements, alcohol, food and diseases
The relevance of a particular drug interaction to a specific individual is difficult to determine