Therapeutic drug monitoring: Digoxin levels are rarely required
5–1micrograms/L (in heart failure)
mL-1 in children, 0
mL-1 in older adults (≥ 65 years) in atrial fibrillation and heart failure
Dec 27, 2023 · Normal and abnormal serum digoxin concentrations
5 nanograms/mL in the absence of hypokalaemia indicate that digoxin toxicity is unlikely
Digoxin also has a role in heart failure
Digoxin toxicity can occur even when the serum digoxin concentration is within the therapeutic range (between 0
The ability of digoxin to reduce sympathetic activation has also been recognized
4 ng/mL
As reported by Smith et al, 20 serum digoxin levels in 10 nontoxic patients (without atrial fibrillation) on oral doses of 0
Digoxin Generic name: digoxin (oral/injection) [ di-JOX-in ] Brand names: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin Drug classes: Group V antiarrhythmics
Treatment of known or strongly suspected life-threatening digoxin toxicity associated with ventricular arrhythmias or bradyarrhythmias unresponsive to atropine and when
Drug Interaction Definition • A clinically meaningful alteration in the effect of one drug as a result of coadministration of
In preparation for this manuscript, ten nationally recognized laboratories were contacted in 2023 by phone to determine their therapeutic ranges for digoxin, only 4/10
Diagnosis is difficult and usually made clinically, as levels of digoxin in the blood
Atrial fibrillation can be managed by either controlling the ventricular rate (‘rate There is a fine line between toxic levels of digoxin and therapeutic levels
1 Post hoc analysis of this trial found that mortality and hospitalisations were reduced if the serum digoxin was 0
Target range: 0
; Scores range from 0 to 7 based on the presence or absence of specific characteristics
Interactions include digoxin and simvastatin (see BNF Appendix 1 for more details)
Digoxin can be used to treat heart failure when symptoms remain despite the use of other drugs
There are no rigid guidelines as to the range of serum concentrations that are most efficacious
4–1 mmol/litre (lower end of the range for maintenance therapy and elderly patients)
25 mg/day for maintenance [4,24] and plasma concentrations of 1-2ug/L are considered to be the limits of the therapeutic range [4, 23] but this has been revised recently to 0
4
Digoxin levels start to plateau at 6 hours, which is after For digoxin-specific antibody Treatment of known or strongly suspected life-threatening digoxin toxicity associated with ventricular arrhythmias or bradyarrhythmias unresponsive to atropine and when measures beyond the withdrawal of digoxin and correction of any electrolyte abnormalities are considered necessary for digoxin-specific antibody However, the narrow therapeutic range of digoxin means that you have to be strict with your medication
In patients taking fixed daily dosage, steady state plasma concentrations vary widely making measurement desirable
Note that toxicity may occur with a level of less than
Most drugs are typically assigned a single therapeutic
Digoxin has been used for more than 200 years in the treatment of patients with Heart Failure (HF) []
It can also help to manage the symptoms of heart failure, usually with other medicines
5 microgram
NICE TA341