Azathioprine thiopurine methyltransferase

Sep 20, 2012 · Thiopurine methyltransferase deficiency is the primary genetic cause of thiopurine intolerance in Europeans and Africans, and NUDT15 deficiency is a more common cause in Asians and Hispanics. Patients with heterozygous deficiency have 50% of enzym

2024-03-19
    Singular logic ιδιοκτητησ
  1. It then inhibits purine synthesis
  2. Table 2
  3. Metabolism of azathioprine, thioguanine, and mercaptopurine Table 1
  4. Patients with homozygous deficiency
  5. Methyltransferases
  6. 2
  7. 1
  8. The
  9. TPMT is the primary metabolic route for