In addition to these data Francis 9 reported the upper critical solution temperature and Schneider 2 reported extensive measurements of the mutual solubility of components (1) and (2) determined between 0
The drug concentrations were quantified by HPLC analysis (Agilent HP 1100, Chemstation, Hewlett Packard, USA)
It is also used to treat bipolar disorder (manic depressive disorder; a disease that causes episodes of Children and adolescent side effects can include the above, plus: headache
It may also be used alone or with other medicines (eg, lithium or valproate) to treat mania or mixed episodes that is part of bipolar disorder (manic-depressive illness)
If any of these effects last or get worse, tell your For treatment of mania or mixed episodes with bipolar disorder (olanzapine alone): Adults—At first, 10 to 15 milligrams (mg) once a day
Olanzapine oral tablets can be used for schizophrenia, bipolar I disorder, and resistant depression
Side effects of olanzapine include: Dizziness/ low blood pressure upon standing
Extrapyramidal symptoms (EPS), dose dependent (muscle spasms, jerky movements, slow movements) Dry mouth
Pain or trouble swallowing
Common Zyprexa side effects may include: weight gain (more likely in teenagers), increased appetite; headache, dizziness, drowsiness, feeling tired or restless; problems with speech or memory; tremors or shaking, numbness or tingly feeling; changes in personality; dry mouth, or increased salivation; stomach pain, constipation; or
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Generic Name Olanzapine DrugBank Accession Number DB00334 Background
It can also increase the risk of falls, due to its tendency to cause dizziness
It is also known by the trade names Zalasta, Zyprexa and ZypAdhera
The combination of olanzapine and samidorphan is also used to prevent episodes of mania in adults with bipolar disorder
itching of the vagina or genital area
Olanzapine belongs to a group of medicines called antipsychotics
large, flat, blue, or purplish patches in the skin
5-20 mg daily (mean dosage of about 9 mg daily)
rate, BP; decr
life-threatening), other Olanzapine (Zyprexa, Zyprexa Zydis) is a moderately priced drug used to treat schizophrenia, psychotic disorders, and bipolar disorder
Drug information provided by: Merative, Micromedex
This medicine should not be used to treat behavioral problems in older adult patients who have dementia or Zyprexa may be taken on a full or empty stomach and should be taken exactly as prescribed by your doctor
It is a disease that causes episodes of depression, mania, and other abnormal moods
2) When using ZYPREXA and fluoxetine in combination, also refer to the Boxed Warning section of the package insert for
1, 2 The availability of olanzapine and the atypical class in general provided psychiatrists with treatment options with reduced risk of motoric adverse effects
females, non-smoker with olanzapine compared to patients treated with placebo (1
Age >75 years and vascular/mixed type dementia were identified as risk factors for CVAE in association with olanzapine treatment
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In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016
These receptor affinities have been shown to relate to recognized clinical and adverse effects of olanzapine
For all the solvents that were tested in the temperature range, we
We found that the solubility increased with the solvent polarity in the order: methanol > ethanol > acetonitrile > ethyl acetate > tetrahydrofuran > toluene
Abstract Crystalline solvates of olanzapine (1 ), 2-methyl-4- (4-methyl-1-piperazinyl)-10 H -thieno [2,3- b ] [1,5]benzodiazepine, have been characterized by an X
A threefold increase in the solubility was observed in olanzapinium 3-hydroxybenzoate and olanzapinium anthranilate, and an almost fivefold increase in
; IC50 Value:; Target: 5-HT Receptor; Olanzapine is a thienobenzodiazepine
According to the DSC thermogram, the solvents can be divided into four classes: those that do not form solvates and leave olanzapine form 1 (ethyl acetate
Crystallization by cooling anhydrous ethyl acetate solution gives the stable form 1 that was used throughout the experimental work
Water can induce polymorphic transition of olanzapine during the preparation of ODF
Keep your regular appointments with your doctor
loss of memory
nervousness
Olanzapine is well absorbed and reaches peak concentrations in approximately 6 hours following an oral dose
May increase to a target dosage of 10 mg daily
Drowsiness (or sleepiness) is one of olanzapine’s most common side effects
Drowsiness, dizziness, lightheadedness, stomach upset, dry mouth, constipation, increased appetite, or weight gain may occur
Olanzapine (Zyprexa, Zyprexa Zydis) is a moderately priced drug used to treat schizophrenia, psychotic disorders, and bipolar disorder
It is also used off-label to prevent nausea and vomiting caused by chemotherapy
Start at 5 mg of oral olanzapine and 20 mg of fluoxetine once daily • Lower starting dose recommended in debilitated or pharmacodynamically sensitive patients or patients with predisposition to hypotensive reactions, or with potential for slowed metabolism (2
1 mL of Sterile Water for Injection to provide a solution containing approximately 5 mg/mL of olanzapine
Hyperprolactinemia (5
The FDA has approved this medication for schizophrenia if the patient is over the age of 13 and bipolar disorder, including mixed or manic episodes
Risperidone may lengthen the amount of slow wave sleep in patients because it has a higher affinity for serotonin 5-HT 2 receptors than does haloperidol
Limited long-term follow-up of infants exposed to olanzapine indicates that infants generally developed normally
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Common side effects of fluoxetine and olanzapine may include: drowsiness, blurred vision, dry mouth; increased appetite, weight gain; trouble concentrating, feeling tired; swelling in your hands or feet; tremor; or
15–1
Olanzapine is a second-generation antipsychotic agent that exhibits a wide array of receptor affinities including 5-HT 2A–C,3,6,7, dopaminergic D 1–5, muscarinic M 1–5, α 1 - adrenergic and histaminergic H 1 receptors (Bymaster et al 1997)
Introduction
Olanzapine belongs to a group of medications called atypical or second-generation antipsychotics